Mechanism of an exaggerated locomotor response to a low-dose challenge of methamphetamine.

@article{Frankel2007MechanismOA,
  title={Mechanism of an exaggerated locomotor response to a low-dose challenge of methamphetamine.},
  author={Paul S. Frankel and Amanda J. Hoonakker and Jonathan P. Danaceau and Glen R. Hanson},
  journal={Pharmacology, biochemistry, and behavior},
  year={2007},
  volume={86 3},
  pages={511-5}
}
Previous studies using phenylethylamine psychostimulants such as amphetamine (AMPH) have demonstrated that pretreatment with a high-dose of drug followed by a low-dose challenge injection (3 h later) results in an exaggerated behavioral response. In order to explore the mechanism of this exaggerated or what has been suggested to be a "sensitized" response, we investigated the effects of methamphetamine (METH) in a similar treatment paradigm. The current study found that, as suggested by… CONTINUE READING

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