Mechanism of amodiaquine-induced supersensitivity to catecholamines.

  title={Mechanism of amodiaquine-induced supersensitivity to catecholamines.},
  author={K. Pandya and M. Jindal and V. V. Kelkar},
  journal={European journal of pharmacology},
  volume={6 3},
Abstract Small doses of amodiaquine moderately potentiated the pressor responses to adrenaline, noradrenaline and tyramine in anaesthetized dogs and rabbits and in spinal or pithed vagotomized dogs. In spinal or pithed animals the tachycardia produced by adrenaline was also augmented. Amodiaquine, however, did not affect the contraction of the nictitating membrane or spleen produced by adrenaline and noradrenaline. The potentiating effect of amodiaquine on pressor responses to catecholamines… 
Amodiaquine-associated adverse effects after inadvertent overdose and after a standard therapeutic dose.
Observations support the assertion that amodiaquine-associated dystonia is an idiosyncratic reaction and less reported adverse effects are likely to increase in parallel with the increased use of amodIAquine as a partner drug for combination therapy of malaria in Ghana.


Mechanism of the pressor effect of amodiaquin and chloroquine in methylamphetamine-pretreated anesthetized dogs.
It is suggested that the pressor effect of these compounds is mediated, to a large extent, through a release of catecholamines from the tissue stores but seemingly not from adrenal medulla, and that the amines are released in the vicinity of receptor sites and not into the general circulation.
Effects of cocaine and antidepressant drugs on the nictitating membrane of the cat.
  • R. Ryall
  • Medicine
    British journal of pharmacology and chemotherapy
  • 1961
The effects of these antidepressant drugs on the nictitating membrane of the spinal cat and the significance of the peripheral effects ofThese antidepressant drugs in relation to their central actions is discussed.
The development of supersensitivity to norepinephrine after pretreatment with reserpine.
In spinal cats pretreated with reserpine, cocaine was found to retain its ability to increase the sensitivity to norepinephrine and time is relatively less important for the development of supersensitivity of the cardiovascular system.
Supersensitivity and subsensitivity to sympathomimetic amines.
The purpose of a critical appraisal of the various hypotheses concerned with the mechanism of supersensitivity to sympathomimetic amines is not so much to belabor the negative aspect as to emphasize the pressing need for the recognition that this field is much more complicated than is generally realized.
Monoamine oxidase inhibitors.
The action of MAO inhibitors bears mainly on those amines which are preferentially metabolized by MAO, and the intra- as well as the extraneuronal amines seem to be increased.
Reflexogenic Areas of the Cardiovascular System
  • C. Heymans
  • Medicine
    Perspectives in biology and medicine
  • 1960
Experiments done between 1877 and 1926 showed that a rise of blood pressure in the carotid-cephalic circulation induces bradycardia and a fall of the systemic arterial pressure, while a drop in the vehicle pressure provokes acceleration of the heart rate and a rise in the systemicarterial pressure.
A preparation of the spinal cat by an anterior approach
A method for preparation of the spinal cat through an anterior approach is described. It has certain advantages over the classical posterior approach and is particularly useful in preparations for
Cardiovascular interactions between acutely administered reserpine and mephentermine.