Mechanism of amodiaquine-induced supersensitivity to catecholamines.

@article{Pandya1969MechanismOA,
  title={Mechanism of amodiaquine-induced supersensitivity to catecholamines.},
  author={K. Pandya and M. Jindal and V. V. Kelkar},
  journal={European journal of pharmacology},
  year={1969},
  volume={6 3},
  pages={
          265-73
        }
}
Abstract Small doses of amodiaquine moderately potentiated the pressor responses to adrenaline, noradrenaline and tyramine in anaesthetized dogs and rabbits and in spinal or pithed vagotomized dogs. In spinal or pithed animals the tachycardia produced by adrenaline was also augmented. Amodiaquine, however, did not affect the contraction of the nictitating membrane or spleen produced by adrenaline and noradrenaline. The potentiating effect of amodiaquine on pressor responses to catecholamines… 
Amodiaquine-associated adverse effects after inadvertent overdose and after a standard therapeutic dose.
TLDR
Observations support the assertion that amodiaquine-associated dystonia is an idiosyncratic reaction and less reported adverse effects are likely to increase in parallel with the increased use of amodIAquine as a partner drug for combination therapy of malaria in Ghana.

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