Mechanism of amide formation by carbodiimide for bioconjugation in aqueous media.

@article{Nakajima1995MechanismOA,
  title={Mechanism of amide formation by carbodiimide for bioconjugation in aqueous media.},
  author={Noriyuki Nakajima and Yoshito Ikada},
  journal={Bioconjugate chemistry},
  year={1995},
  volume={6 1},
  pages={123-30}
}
To study the mechanism of amide formation between carboxylic acid and amine in aqueous media using 1-ethyl-3-(3-(dimethylamino)propyl)carbodiimide hydrochloride (EDC), hydrogels with two different types of carboxyl group locations were employed as substrates containing the carboxylic acid, while ethylenediamine and benzylamine were used as amine. In parallel, a study was undertaken with cyclizable carboxylic acids (maleic acid and poly(acrylic acid) and noncyclizable carboxylic acids (fumaric… CONTINUE READING
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