Mechanism of alpha-lipoic acid in attenuating kanamycin-induced ototoxicity☆

@inproceedings{Wang2012MechanismOA,
  title={Mechanism of alpha-lipoic acid in attenuating kanamycin-induced ototoxicity☆},
  author={Aimei Wang and Ning Hou and Dongyan Bao and Shuangyue Liu and Tao Xu},
  booktitle={Neural regeneration research},
  year={2012}
}
In view of the theory that alpha-lipoic acid effectively prevents cochlear cells from injury caused by various factors such as cisplatin and noise, this study examined whether alpha-lipoic acid can prevent kanamycin-induced ototoxicity. To this end, healthy BALB/c mice were injected subcutaneously with alpha-lipoic acid and kanamycin for 14 days. Auditory brainstem response test showed that increased auditory brainstem response threshold shifts caused by kanamycin were significantly inhibited… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 40 references

Effect of α-lipoic acid on kanamycin-induced expression of phosphorylated p38 MAPK in mouse cochlea

  • N Hou, AM Wang, CF Bao
  • Zhongguo Laonian Xue Zazhi
  • 2012
2 Excerpts

Apoptosis pathway in mouse cochlear due to kanamycin

  • L Yu, H Tang, AM. Wang
  • Guangdong Yixue
  • 2011
1 Excerpt

Effect of amikacin on the expression of phosphorylated JNK in hair cells of guinea pig cochlea

  • SY Liu, AM Wang, T Xu
  • Zhongguo Laonian Xue Zazhi
  • 2011
2 Excerpts

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