Mechanism of alpha-lipoic acid in attenuating kanamycin-induced ototoxicity☆

  title={Mechanism of alpha-lipoic acid in attenuating kanamycin-induced ototoxicity☆},
  author={Aimei Wang and Ning Hou and Dongyan Bao and Shuangyue Liu and Tao Xu},
  booktitle={Neural regeneration research},
In view of the theory that alpha-lipoic acid effectively prevents cochlear cells from injury caused by various factors such as cisplatin and noise, this study examined whether alpha-lipoic acid can prevent kanamycin-induced ototoxicity. To this end, healthy BALB/c mice were injected subcutaneously with alpha-lipoic acid and kanamycin for 14 days. Auditory brainstem response test showed that increased auditory brainstem response threshold shifts caused by kanamycin were significantly inhibited… CONTINUE READING
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