Mechanism of alamethicin insertion into lipid bilayers.

@article{He1996MechanismOA,
  title={Mechanism of alamethicin insertion into lipid bilayers.},
  author={Kai He and Steven J. Ludtke and William T. Heller and Huey W Huang},
  journal={Biophysical journal},
  year={1996},
  volume={71 5},
  pages={2669-79}
}
Alamethicin adsorbs on the membrane surface at low peptide concentrations. However, above a critical peptide-to-lipid ratio (P/L), a fraction of the peptide molecules insert in the membrane. This critical ratio is lipid dependent. For diphytanoyl phosphatidylcholine it is about 1/40. At even higher concentrations P/L > or = 1/15, all of the alamethicin inserts into the membrane and forms well-defined pores as detected by neutron in-plane scattering. A previous x-ray diffraction measurement… CONTINUE READING

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