Mechanism of alamethicin insertion into lipid bilayers.

  title={Mechanism of alamethicin insertion into lipid bilayers.},
  author={Kai He and Steven J. Ludtke and William T. Heller and Huey W Huang},
  journal={Biophysical journal},
  volume={71 5},
Alamethicin adsorbs on the membrane surface at low peptide concentrations. However, above a critical peptide-to-lipid ratio (P/L), a fraction of the peptide molecules insert in the membrane. This critical ratio is lipid dependent. For diphytanoyl phosphatidylcholine it is about 1/40. At even higher concentrations P/L > or = 1/15, all of the alamethicin inserts into the membrane and forms well-defined pores as detected by neutron in-plane scattering. A previous x-ray diffraction measurement… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 56 extracted citations

Alamethicin influence on the membrane bending elasticity

European Biophysics Journal • 2005
View 5 Excerpts
Highly Influenced

Alamethicin for using in bioavailability studies? - Re-evaluation of its effect.

Toxicology in vitro : an international journal published in association with BIBRA • 2017
View 1 Excerpt


Publications referenced by this paper.
Showing 1-10 of 22 references

X-ray Diffraction

Nature • 1970
View 10 Excerpts
Highly Influenced

Studies of amphiphilic helical peptides interacting with lipid bilayer membranes by x - ray and neutron scattering

S. J. Ludtke

Discrete harmonic model for stacked membranes: theory and experiment

Safinya, R. F. Bruinsma.
J. • 1995

Interaction of Lipid Bilayer Membranes with Amphiphilic Helical Peptides in Short and Long Chains at Interfaces

Heller, S. J. Ludtke.
J. • 1995

Theory of the structure factor of lipid bilayers.

Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics • 1994
View 1 Excerpt

Similar Papers

Loading similar papers…