Mechanism of adenosine receptor-induced renal vasoconstriction in rats.

  title={Mechanism of adenosine receptor-induced renal vasoconstriction in rats.},
  author={Noreen F Rossi and Paul C Churchill and Vickie Ellis and Ben Amore},
  journal={The American journal of physiology},
  volume={255 4 Pt 2},
Adenosine analogues selective for the A1 subclass of adenosine receptors, such as N6-cyclohexyladenosine (CHA), induce vasoconstriction in the isolated rat kidney perfused at constant flow. Presumably, the vasoconstriction is mediated by increased Ca2+ concentration in renal vascular smooth muscle cells, but the mechanism by which A1 adenosine receptor occupation leads to increased Ca2+ is unknown. In the present experiments, the isolated, perfused rat kidney vasoconstricted in response to CHA… CONTINUE READING


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