Mechanism of active shrinkage in mitochondria. II. Coupling between strong electrolyte fluxes.

@article{Azzone1976MechanismOA,
  title={Mechanism of active shrinkage in mitochondria. II. Coupling between strong electrolyte fluxes.},
  author={Giovanni Felice Azzone and S Massair and Tullio Pozzan},
  journal={Biochimica et biophysica acta},
  year={1976},
  volume={423 1},
  pages={27-41}
}
1. Addition of succinate to valinomycin-treated mitochondria incubated in KCL causes a large electrolyte penetration. The process depends on a steady supply of energy and involves a continuous net extrusion of protons. Rates of respiration and of electrolyte penetration proceed in a parallel manner. 2. A passive penetration of K+ salt of permeant anions occurs in respiratory-inhibited mitochondria after addition of valinomycin. Addition of succinate at the end of the passive swelling starts an… CONTINUE READING

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