Mechanism of activation of the heme-stabilized translational inhibitor of reticulocyte lysates by calcium ions and phospholipid ( inhibition of translation / protein phosphorylation / lipoperoxide formation / Ca 2 l and phospholipid in translational control )


We have reported previously that calcium ions and phospholipid activate the heme-stabilized proinhibitor form (pro-HCI) of the heme-controlled translational inhibitor (HCI) in reticulocyte lysates and promote the first step of the reaction pro-HCI = reversible HCI -irreversible HCI. This suggested the possible involvement of a Ca2+/phospholipiddependent… (More)

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