Mechanism of activation of the GM-CSF, IL-3, and IL-5 family of receptors.

@article{Guthridge1998MechanismOA,
  title={Mechanism of activation of the GM-CSF, IL-3, and IL-5 family of receptors.},
  author={Mark A. Guthridge and Frank C. Stomski and Daniel T Thomas and Joanna M Woodcock and Christopher J. Bagley and Michael C. Berndt and Angel F Lopez},
  journal={Stem cells},
  year={1998},
  volume={16 5},
  pages={301-13}
}
The process of ligand binding leading to receptor activation is an ordered and sequential one. High-affinity binding of GM-CSF, interleukin 3 (IL-3), and IL-5 to their receptors induces a number of key events at the cell surface and within the cytoplasm that are necessary for receptor activation. These include receptor oligomerization, activation of tyrosine kinase activity, phosphorylation of the receptor, and the recruitment of SH2 (src-homology) and PTB (phosphotyrosine binding) domain… CONTINUE READING

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