Mechanism of activation of elongation factor Tu by ribosome: catalytic histidine activates GTP by protonation.

Abstract

Elongation factor Tu (EF-Tu) is central to prokaryotic protein synthesis as it has the role of delivering amino-acylated tRNAs to the ribosome. Release of EF-Tu, after correct binding of the EF-Tu:aa-tRNA complex to the ribosome, is initiated by GTP hydrolysis. This reaction, whose mechanism is uncertain, is catalyzed by EF-Tu, but requires activation by… (More)
DOI: 10.1261/rna.040097.113

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