Mechanism of activation of early viral transcription by the adenovirus E1A gene product.

Abstract

Results obtained with certain adenovirus host range mutants (dl312 and hr1) have demonstrated that a functional viral E1A gene is required for the accumulation of early viral mRNA. In this report, it is demonstrated that the failure to accumulate early viral mRNA in E1A mutant-infected cells is due to a lack of transcription of the appropriate transcription… (More)

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