Mechanism of activation of branched-chain alpha-keto acid dehydrogenase complex by exercise.

  title={Mechanism of activation of branched-chain alpha-keto acid dehydrogenase complex by exercise.},
  author={Mei Xu and Masaru Nagasaki and Mariko Obayashi and Yasufumi Sato and Tomohiro Tamura and Yoshiharu Shimomura},
  journal={Biochemical and biophysical research communications},
  volume={287 3},
Branched-chain alpha-keto acid dehydrogenase (BCKDH) complex catalyzes the committed step of branched-chain amino acid catabolism, and its activity is regulated by the phosphorylation-dephosphorylation cycle. BCKDH kinase is responsible for inactivation of the complex by phosphorylation. In the present study, we examined acute exercise on the activity state of the complex as well as the amounts of bound and free forms of the kinase in rat liver and skeletal muscle. Acute exercise activated the… CONTINUE READING

From This Paper

Topics from this paper.


Publications citing this paper.
Showing 1-7 of 7 extracted citations

Exercise training increases branched-chain oxoacid dehydrogenase kinase content in human skeletal muscle.

American journal of physiology. Regulatory, integrative and comparative physiology • 2007
View 6 Excerpts
Highly Influenced

Branched-chain amino acid supplementation before squat exercise and delayed-onset muscle soreness.

International journal of sport nutrition and exercise metabolism • 2010
View 1 Excerpt

Similar Papers

Loading similar papers…