Mechanism of action of vigabatrin: correcting misperceptions

@article{BenMenachem2011MechanismOA,
  title={Mechanism of action of vigabatrin: correcting misperceptions},
  author={Elinor Ben-Menachem},
  journal={Acta Neurologica Scandinavica},
  year={2011},
  volume={124}
}
  • E. Ben-Menachem
  • Published 8 November 2011
  • Medicine
  • Acta Neurologica Scandinavica
Ben‐Menachem E. Mechanism of action of vigabatrin: correcting misperceptions.
Acta Neurol Scand: 2011: 124 (Suppl. 192): 5–15.
© 2011 John Wiley & Sons A/S. 

Paper Mentions

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© 2011 John Wiley & Sons A/S.
Understanding and interpreting vision safety issues with vigabatrin therapy
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Acta Neurol Scand: 2011: 124 (Suppl. 192): 57–71.
© 2011 John Wiley & Sons A/S.
Non‐vision adverse events with vigabatrin therapy
Walker SD, Kälviäinen R. Non‐vision adverse events with vigabatrin therapy.
Acta Neurol Scand: 2011: 124 (Suppl. 192): 72–82.
© 2011 John Wiley & Sons A/S.
Vigabatrin therapy for refractory complex partial seizures: review of major European trials
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Vigabatrin therapy for refractory complex partial seizures: review of major European trials. Expand
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To compare the therapeutic effectiveness of oral corticosteroids with that of adrenocorticotrophic hormone for infantile spasms, a comparison study is conducted at the National Institutes of Health. Expand
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Carmant L. Vigabatrin therapy for infantile spasms: review of major trials in Europe, Canada, and the United States; and recommendations for dosing.
Acta Neurol Scand: 2011: 124 (Suppl. 192): 36–47.Expand
Effect of vigabatrin on seizure control and safety profile in different subgroups of children with epilepsy
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Reconsideration of Vigabatrin Effect in Infantile Spasms Treatment
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VGB is effective enough to become a first-line drug for children with IS and better prognosis can be expected in patients with clinical remission of hypsarrhythmia on electroencephalography after treatment initiation using VGB compared to those who do not have such remission. Expand
Vigabatrin‐associated retinal damage – potential biochemical mechanisms
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References

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Understanding and interpreting vision safety issues with vigabatrin therapy
Plant GT, Sergott RC. Understanding and interpreting vision safety issues with vigabatrin therapy.
Acta Neurol Scand: 2011: 124 (Suppl. 192): 57–71.
© 2011 John Wiley & Sons A/S.
Non‐vision adverse events with vigabatrin therapy
Walker SD, Kälviäinen R. Non‐vision adverse events with vigabatrin therapy.
Acta Neurol Scand: 2011: 124 (Suppl. 192): 72–82.
© 2011 John Wiley & Sons A/S.
Vigabatrin therapy for refractory complex partial seizures: review of major European trials
TLDR
Vigabatrin therapy for refractory complex partial seizures: review of major European trials. Expand
Vigabatrin Versus ACTH as First‐Line Treatment for Infantile Spasms: A Randomized, Prospective Study
TLDR
To compare the efficacy and tolerability of vigabatrin (VGB) and adrenocorticotrophic hormone (ACTH) as first‐line therapy in infantile spasms is compared. Expand
Randomised, Placebo‐Controlled Study of Vigabatrin as First‐Line Treatment of Infantile Spasms
TLDR
This prospective, randomised, and placebo‐controlled trial of VGB in infantile spasms was considered to be justified and feasible to confirm or refute these previous findings. Expand
Vigabatrin therapy for refractory complex partial seizures: review of clinical trial experience in the United States
  • E. Faught
  • Medicine
  • Acta neurologica Scandinavica. Supplementum
  • 2011
Faught E. Vigabatrin therapy for refractory complex partial seizures: review of clinical trial experience in the United States.
Acta Neurol Scand: 2011: 124 (Suppl. 192): 29–35.
© 2011 John Wiley &Expand
Vigabatrin therapy for infantile spasms: review of major trials in Europe, Canada, and the United States; and recommendations for dosing
  • L. Carmant
  • Medicine
  • Acta neurologica Scandinavica. Supplementum
  • 2011
Carmant L. Vigabatrin therapy for infantile spasms: review of major trials in Europe, Canada, and the United States; and recommendations for dosing.
Acta Neurol Scand: 2011: 124 (Suppl. 192): 36–47.Expand
GABAergic drugs in the treatment of epilepsy: modern or outmoded?
  • M. Mula
  • Medicine
  • Future medicinal chemistry
  • 2011
TLDR
The challenge will be to find GABAergic drugs that exhibit the beneficial effects, without the adverse ones, of GABAergic antiepileptic drugs. Expand
Dose–Response Study of Vigabatrin as Add‐On Therapy in Patients with Uncontrolled Complex Partial Seizures
TLDR
The efficacy and safety of three daily doses of vigabatrin as add‐on therapy as add-on therapy in 174 patients with previously uncontrolled complex partial seizures with or without secondary generalization were examined. Expand
Vigabatrin, but not Gabapentin or Topiramate, Produces Concentration‐related Effects on Enzymes and Intermediates of the GABA Shunt in Rat Brain and Retina
Summary:  Purpose: The antiepileptic drug (AED) vigabatrin (VGB), which exerts its pharmacologic effects on the γ‐aminobutyric acid (GABA) system, causes concentric visual field constriction in >40%Expand
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