Mechanism of action of vaccine therapy in murine hepatitis B virus carriers: vaccine-induced activation of antigen presenting dendritic cells.

@article{Akbar1999MechanismOA,
  title={Mechanism of action of vaccine therapy in murine hepatitis B virus carriers: vaccine-induced activation of antigen presenting dendritic cells.},
  author={Sk Md Fazle Akbar and Masanori Abe and Taeko Masumoto and Norio Horiike and Morikazu Onji},
  journal={Journal of hepatology},
  year={1999},
  volume={30 5},
  pages={755-64}
}
BACKGROUND/AIMS Vaccine therapy in which vaccine containing hepatitis B surface antigen (HBsAg) is injected has shown therapeutic activity (vaccine therapy) in some human and murine chronic hepatitis B virus (HBV)-carriers. Using HBV-transgenic mice (HBV-Tg), an animal model of the HBV-carrier state, the mechanism underlying the antiviral and immune modulatory capacity of vaccine therapy was studied. METHODS Placebo-controlled, double-blind trials of vaccine therapy were conducted in HBV-Tg… CONTINUE READING
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