Mechanism of action of tubulysin, an antimitotic peptide from myxobacteria.

  title={Mechanism of action of tubulysin, an antimitotic peptide from myxobacteria.},
  author={Mohamed W Khalil and Florenz Sasse and Heinrich Luensdorf and Yasser A. Elnakady and Hans Reichenbach},
  journal={Chembiochem : a European journal of chemical biology},
  volume={7 4},
Tubulysin A is a highly cytotoxic peptide with antimitotic activity that induces depletion of cell microtubules and triggers the apoptotic process. Treated cells accumulated in the G2/M phase. Tubulysin A inhibited tubulin polymerization more efficiently than vinblastine and induced depolymerization of isolated microtubule preparations. Microtubule depolymerization could not be prevented by preincubation with epothilone B and paclitaxel, neither in cell-free systems nor in cell lines. In… CONTINUE READING
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