Mechanism of action of the lexA gene product.

  title={Mechanism of action of the lexA gene product.},
  author={Roger Brent and Mark Ptashne},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={78 7},
Genetic experiments have suggested that the lexA gene product of Escherichia coli represses a number of genes involved in the response to DNA damage, including recA and lexA. We purified the lexA gene product from bacterial strains that bear plasmids that direct the synthesis of large amounts of the protein. Purified lexA protein bound to two symmetrical DNA sequences in front of lexA and one in front of recA, protecting them from digestion with DNase I and blocking methylation of purines in… CONTINUE READING

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