Mechanism of action of the antirhinovirus flavanoid 4',6-dicyanoflavan.

@article{Conti1992MechanismOA,
  title={Mechanism of action of the antirhinovirus flavanoid 4',6-dicyanoflavan.},
  author={C. Conti and P. Tomao and D. Genovese and N. Desideri and M. Stein and N. Orsi},
  journal={Antimicrobial Agents and Chemotherapy},
  year={1992},
  volume={36},
  pages={95 - 99}
}
  • C. Conti, P. Tomao, +3 authors N. Orsi
  • Published 1992
  • Biology, Medicine
  • Antimicrobial Agents and Chemotherapy
  • 4',6-Dicyanoflavan (DCF), a new antirhinovirus compound, was shown to inhibit an early event of rhinovirus type 1B replication in HeLa cells. When DCF was present from the beginning of infection or was added no later than the first hour of infection, the compound completely prevented viral RNA and protein synthesis and the virus-induced shutoff of host translation. DCF had no adverse effect either on virus binding to the cell membrane or on virus penetration into cells, whereas it delayed the… CONTINUE READING
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    References

    SHOWING 1-10 OF 22 REFERENCES
    Effect of dichloroflavan (BW683C) on the stability and uncoating of rhinovirus type 1B.
    • 34
    Activities and mechanisms of action of halogen-substituted flavanoids against poliovirus type 2 infection in vitro.
    • 30
    • PDF
    Inhibition of an early stage of rhinovirus replication by dichloroflavan (BW683C).
    • 36
    Effect of isoflavans and isoflavenes on the infection of Frp/3 cells by hepatitis A virus.
    • 30
    4′,6-Dichloroflavan (BW683C), a new anti-rhinovirus compound
    • 146
    The effects of concanavalin A on the early events of infection by rhinovirus type 2 and poliovirus type 2.
    • 45
    Effect of isoflavans and isoflavenes on rhinovirus 1B and its replication in HeLa cells.
    • 28
    Inhibition of respiratory syncytial virus-host cell interactions by mono- and diamidines.
    • 39
    • PDF
    In vitro effect of synthetic flavanoids on astrovirus infection.
    • 17
    Synthesis and anti-rhinovirus activity of halogen-substituted isoflavenes and isoflavans
    • 40