Mechanism of action of the antirhinovirus flavanoid 4',6-dicyanoflavan.

  title={Mechanism of action of the antirhinovirus flavanoid 4',6-dicyanoflavan.},
  author={C. Conti and P. Tomao and D. Genovese and N. Desideri and M. Stein and N. Orsi},
  journal={Antimicrobial Agents and Chemotherapy},
  pages={95 - 99}
  • C. Conti, P. Tomao, +3 authors N. Orsi
  • Published 1992
  • Biology, Medicine
  • Antimicrobial Agents and Chemotherapy
  • 4',6-Dicyanoflavan (DCF), a new antirhinovirus compound, was shown to inhibit an early event of rhinovirus type 1B replication in HeLa cells. When DCF was present from the beginning of infection or was added no later than the first hour of infection, the compound completely prevented viral RNA and protein synthesis and the virus-induced shutoff of host translation. DCF had no adverse effect either on virus binding to the cell membrane or on virus penetration into cells, whereas it delayed the… CONTINUE READING
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