Mechanism of action of the antineoplastic drug lonidamine: 31P and 13C nuclear magnetic resonance studies.

@article{BenHorin1995MechanismOA,
  title={Mechanism of action of the antineoplastic drug lonidamine: 31P and 13C nuclear magnetic resonance studies.},
  author={Hava Ben-Horin and Maria Tassini and Antonio Vivi and Gil Navon and Ofer Kaplan},
  journal={Cancer research},
  year={1995},
  volume={55 13},
  pages={2814-21}
}
The mechanism of action of the antineoplastic drug lonidamine (LND) on MCF-7 human breast cancer cells was studied with the use of 31P and 13C nuclear magnetic resonance (NMR) spectroscopy. The cells were embedded in alginate microcapsules, perfused with growth media and LND at physiological conditions in the NMR tube, and continuously monitored in vivo for the effects of LND. 31P NMR demonstrated intracellular acidification after LND perfusion concomitant with ATP depletion and changes in… CONTINUE READING

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