Mechanism of action of the antibiotic NXL101, a novel nonfluoroquinolone inhibitor of bacterial type II topoisomerases.

@article{Black2008MechanismOA,
  title={Mechanism of action of the antibiotic NXL101, a novel nonfluoroquinolone inhibitor of bacterial type II topoisomerases.},
  author={Michael T. Black and Th{\'e}r{\`e}se Stachyra and Denis Platel and Anne-Marie Girard and Monique Claudon and J M Bruneau and Christine Miossec},
  journal={Antimicrobial agents and chemotherapy},
  year={2008},
  volume={52 9},
  pages={3339-49}
}
NXL101 is one of a new class of quinoline antibacterial DNA gyrase and topoisomerase IV inhibitors showing potent activity against gram-positive bacteria, including methicillin- and fluoroquinolone-resistant strains. NXL101 inhibited topoisomerase IV more effectively than gyrase from Escherichia coli, whereas the converse is true of enzymes from Staphylococcus aureus. This apparent target preference is opposite to that which is associated with most fluoroquinolone antibiotics. In vitro… CONTINUE READING
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