Mechanism of action of tetanus and botulinum neurotoxins.

  title={Mechanism of action of tetanus and botulinum neurotoxins.},
  author={Cesare Montecucco and Giampietro Schiavo},
  journal={Molecular microbiology},
  volume={13 1},
The clostridial neurotoxins responsible for tetanus and botulism are metallo-proteases that enter nerve cells and block neurotransmitter release via zinc-dependent cleavage of protein components of the neuroexocytosis apparatus. Tetanus neurotoxin (TeNT) binds to the presynaptic membrane of the neuromuscular junction and is internalized and transported retroaxonally to the spinal cord. Whilst TeNT causes spastic paralysis by acting on the spinal inhibitory interneurons, the seven serotypes of… CONTINUE READING


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