Mechanism of action of spiramycin and other macrolides.

  title={Mechanism of action of spiramycin and other macrolides.},
  author={Anne Brisson-No{\"e}l and Patrick Trieu-Cuot and Patrice Courvalin},
  journal={The Journal of antimicrobial chemotherapy},
  volume={22 Suppl B},
Macrolide antibiotics constitute a group of 12 to 16-membered lactone rings substituted with one or more sugar residues, some of which may be amino sugars. They inhibit bacterial protein synthesis both in vivo and in vitro with varying potencies. Macrolides are generally bacteriostatic, although some of these drugs may be bactericidal at very high concentrations. The mechanism of action of macrolides has been a matter of controversy for some time. Spiramycin, a 16-membered macrolide, inhibits… CONTINUE READING
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