Mechanism of action of sphingolipids and their metabolites in the toxicity of fumonisin B1.

@article{Soriano2005MechanismOA,
  title={Mechanism of action of sphingolipids and their metabolites in the toxicity of fumonisin B1.},
  author={J. M. Soriano and Lillian Gonz{\'a}lez and Angel Catala},
  journal={Progress in lipid research},
  year={2005},
  volume={44 6},
  pages={345-56}
}
Fumonisins are a group of mycotoxins produced primarily by Fusarium moniliforme. Several fumonisins have been isolated through out the years but only fumonisin B1, B2 and B3 are the ones present in naturally contaminated foods, with B1 being the most toxic between them. The structural similarity between sphinganine and fumonisin B1 suggests that the mechanism of action of this mycotoxin is mainly via disruption of sphingolipid metabolism, this is an important step in the cascade of events… CONTINUE READING

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