Mechanism of action of rituximab

@article{Cerny2002MechanismOA,
  title={Mechanism of action of rituximab},
  author={Thomas Cerny and Bettina Borisch and Martino Introna and Peter W M Johnson and Andrea L. Rose},
  journal={Anti-Cancer Drugs},
  year={2002},
  volume={13},
  pages={S3–S10}
}
&NA; Rituximab, the humanized chimeric anti‐CD20 monoclonal antibody, represents a powerful tool for treating B‐cell malignancies and is licensed for the treatment of relapsed or chemorefractory low‐grade or follicular non‐Hodgkin's lymphoma (NHL). It has a unique mode of action and can induce killing of CD20+ cells via multiple mechanisms. The direct effects of rituximab include complement‐mediated cytotoxicity and antibody‐dependent cellmediated cytotoxicity, and the indirect effects include… 
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