Mechanism of action of newly developed vitamin D analogue.


26,27-F6-1,25(OH)2D3 has a higher potency both in vivo and in vitro systems, and longer duration of action in vivo, instead of almost equal binding to 1,25(OH)2D3 receptor and comparatively short serum half-life. To date, the mechanism of higher action is not known, but using these analogues as a mirror we might be able to elucidate the mechanism of action or the metabolism of the kidney hormone, 1,25(OH)2D3.

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@article{Okamoto1991MechanismOA, title={Mechanism of action of newly developed vitamin D analogue.}, author={Shinichiro Okamoto and Eri Ejima and Takeshi Kiriyama and Miki Izumi and Asako Komori and Hiroko Suzuki and Toshiya Katsumata and Akihiko Nagata}, journal={Contributions to nephrology}, year={1991}, volume={91}, pages={146-8} }