Mechanism of action of methylphenidate: Insights from PET imaging studies

@article{Volkow2002MechanismOA,
  title={Mechanism of action of methylphenidate: Insights from PET imaging studies},
  author={N. Volkow and J. Fowler and G. Wang and Y. Ding and S. Gatley},
  journal={Journal of Attention Disorders},
  year={2002},
  volume={6},
  pages={31 - 43}
}
Methylphenidate (MPH) is the most commonly prescribed drug for the treatment of Attention-Deficit/Hyperactivity Disorder (ADHD). We have used Positron Emission Tomography (PET) to investigate the mechanism of action of MPH in the human brain. We have shown (a) that oral MPH reaches peak concentration in the brain 60–90 minutes after its administration, (b) that therapeutic doses of MPH block more than 50% of the dopamine transporters (DAT), and (c) that of the two enantiomers that compose MPH… Expand
289 Citations

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