Mechanism of action of magnesium on acetylcholine-evoked secretory responses in isolated rat pancreas.

@article{Francis1990MechanismOA,
  title={Mechanism of action of magnesium on acetylcholine-evoked secretory responses in isolated rat pancreas.},
  author={Leslie Pickering Francis and R. Lennard and Jaswant Singh},
  journal={Experimental physiology},
  year={1990},
  volume={75 5},
  pages={
          669-80
        }
}
This study investigates the effects of magnesium (Mg2+) on acetylcholine (ACh)-evoked secretory responses and calcium (Ca2+) mobilization in the isolated rat pancreas. ACh induced marked dose-dependent increases in total protein output and amylase release from superfused pancreatic segments in zero, normal (1 x 1 mM) and elevated (10 mM) extracellular Mg2+. Elevated Mg2+ attenuated the ACh-evoked secretory responses compared to zero and normal Mg2+. In the absence of extracellular Ca2+, but… CONTINUE READING

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