Mechanism of action of lead on neuromuscular junctions.

  title={Mechanism of action of lead on neuromuscular junctions.},
  author={William D. Atchison and Toshio Narahashi},
  volume={5 3},
Effects of bath-applied lead acetate on nerve-evoked and spontaneous neurotransmitter release were studied at the neuromuscular junction of the rat using conventional microelectrode recording techniques. Lead (20, 100 microM) depressed end-plate potential (EPP) amplitude within 5 min of application without affecting miniature end-plate potential (MEPP) amplitude. Increasing bath Ca2+ concentration from 2 mM to 4 or 8 mM caused a concentration-dependent reversal of lead-induced block of nerve… CONTINUE READING


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