Mechanism of action of ixabepilone and its interactions with the βIII-tubulin isotype
@article{Lopus2015MechanismOA, title={Mechanism of action of ixabepilone and its interactions with the $\beta$III-tubulin isotype}, author={Manu Lopus and Gregoriy Smiyun and Herbert P. Miller and Emin Oroudjev and Leslie Wilson and Mary Ann Jordan}, journal={Cancer Chemotherapy and Pharmacology}, year={2015}, volume={76}, pages={1013-1024} }
Ixabepilone (Ixempra, BMS-247550), a semisynthetic analog of epothilone B, is a microtubule-targeted drug in clinical use for treatment of metastatic or locally advanced breast cancer. [] Key Result The βIII isotype of tubulin is associated with drug resistance and tumor aggressivity. We found that removal (in vitro) and knockdown (in cells) of βIII-tubulin led to increased inhibition of microtubule dynamic instability by ixabepilone.
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