• Corpus ID: 6621419

Mechanism of action of tetra-mu-carboxylatodirhodium(II) in L1210 tumor suspension culture.

  title={Mechanism of action of tetra-mu-carboxylatodirhodium(II) in L1210 tumor suspension culture.},
  author={R. A. Howard and A. P. Kimball and John L. Bear},
  journal={Cancer research},
  volume={39 7 Pt 1},
The effect of tetrakis-mu-methoxyacetato, tetra-mu-acetato, tetra-mu-propionato, and tetra-mu-butyratodirhodium(II) on the proliferation and macromolecular synthesis of leukemia L1210 cells in suspension culture was evaluated. The cytotoxicity of these dimeric rhodium(II) complexes to tumor cells in suspension culture follows the same trend as observed in vivo, i.e., butyrato greater than propionato greater than acetato greater than methoxyacetato. The cellular synthesis of DNA and protein was… 

Reactions of Antitumor Active Dirhodium(II) Tetraacetate Rh2(CH3COO)4 with Cysteine and Its Derivatives

Results from several spectroscopic techniques are combined to investigate the aerobic reactions of Rh2(AcO)4 with l-cysteine and its derivatives d-penicillamine, with steric hindrance at the thiol group, and N-acetyl-l- Cysteine (H2NAC), with its amino group blocked.

Chapter 14. Antineoplastic Agents

Live cell cytotoxicity studies: documentation of the interactions of antitumor active dirhodium compounds with nuclear DNA.

The DNA interactions and activity in living cells of six monosubstituted dirhodium(II,II) complexes suggest that glutathione is not the only agent involved in the deactivation of these Dirhodium complexes, and data from modulation studies of glutathionine and L-buthionine-sulfoximine indicate that changes in glutATHione levels do not affect the activity of these particular dirhodia complexes.

Anticancer dirhodium(II,II) carboxylates as potent inhibitors of ubiquitin-proteasome system

The findings revealed that the dirhodium(II,II) carboxylates exhibit potent UPS inhibitory property which is linked to their cytotoxic actions.

Synthesis of dirhodium[3H]tetraacetate

This labeled material can be synthesized with greatly increased specific activity of tritium in acetate groups by employing [3H]NaOAc without prior dilution and is stable and yields a characteristic product with adenylic acid.

Chelate Structure of a Dirhodium–Amino Acid Complex Identified by Chiroptical and NMR Spectroscopy

Dinuclear rhodium complexes have attracted considerable attention as a result of their chemical and biological reactivity. We report herein the synthesis and structural elucidation by combined