• Corpus ID: 6621419

Mechanism of action of tetra-mu-carboxylatodirhodium(II) in L1210 tumor suspension culture.

@article{Howard1979MechanismOA,
  title={Mechanism of action of tetra-mu-carboxylatodirhodium(II) in L1210 tumor suspension culture.},
  author={R. A. Howard and A. P. Kimball and John L. Bear},
  journal={Cancer research},
  year={1979},
  volume={39 7 Pt 1},
  pages={
          2568-73
        }
}
The effect of tetrakis-mu-methoxyacetato, tetra-mu-acetato, tetra-mu-propionato, and tetra-mu-butyratodirhodium(II) on the proliferation and macromolecular synthesis of leukemia L1210 cells in suspension culture was evaluated. The cytotoxicity of these dimeric rhodium(II) complexes to tumor cells in suspension culture follows the same trend as observed in vivo, i.e., butyrato greater than propionato greater than acetato greater than methoxyacetato. The cellular synthesis of DNA and protein was… 
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