Mechanism of action of hydroxyurea in the management of sickle cell anemia in adults.

@article{Charache1997MechanismOA,
  title={Mechanism of action of hydroxyurea in the management of sickle cell anemia in adults.},
  author={Samuel Charache},
  journal={Seminars in hematology},
  year={1997},
  volume={34 3 Suppl 3},
  pages={15-21}
}
In a randomized, placebo-controlled clinical trial, treatment with hydroxyurea (HU) reduced crisis rates in adult patients with severe sickle cell anemia. No serious acute toxicity was seen, but the safety of long-term therapy could not be evaluated. The rationale for the use of HU was based on its ability to increase fetal hemoglobin (HbF) synthesis and the inhibitory effect of HbF on polymerization of sickle cell hemoglobin. Surprisingly, final HbF levels in patients assigned to HU did not… CONTINUE READING

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