Mechanism of action of glatiramer acetate in multiple sclerosis and its potential for the development of new applications.

@article{Arnon2004MechanismOA,
  title={Mechanism of action of glatiramer acetate in multiple sclerosis and its potential for the development of new applications.},
  author={Ruth Arnon and Rina Aharoni},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 Suppl 2},
  pages={14593-8}
}
Glatiramer acetate (GA, Copaxone, Copolymer 1) is an approved drug for the treatment of multiple sclerosis and is highly effective in the suppression of experimental autoimmune encephalomyelitis in various species. The mode of action of GA is by initial strong promiscuous binding to MHC molecules and consequent competition with various myelin antigens for their presentation to T cells. A further aspect of its action is potent induction of specific suppressor cells of the T helper 2 (Th2) type… CONTINUE READING

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