Mechanism of action of fibrates on lipid and lipoprotein metabolism.

@article{Staels1998MechanismOA,
  title={Mechanism of action of fibrates on lipid and lipoprotein metabolism.},
  author={Bart Staels and Jean Dallongeville and Johan Auwerx and Kristina Schoonjans and Eran Leitersdorf and J. C. Fruchart},
  journal={Circulation},
  year={1998},
  volume={98 19},
  pages={
          2088-93
        }
}
Treatment with fibrates, a widely used class of lipid-modifying agents, results in a substantial decrease in plasma triglycerides and is usually associated with a moderate decrease in LDL cholesterol and an increase in HDL cholesterol concentrations. Recent investigations indicate that the effects of fibrates are mediated, at least in part, through alterations in transcription of genes encoding for proteins that control lipoprotein metabolism. Fibrates activate specific transcription factors… CONTINUE READING
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