Mechanism of action of colchicine. VI: Effect of colchicine on generation of leukotriene B4 by human polymorphonuclear leukocytes.


Three microtubule-disruptive agents (colchicine, oncodazole, and vinblastine) are shown to suppress ionophore A23187-induced generation of LTB4 in a dose-related manner. The slopes of the dose-response regression lines were similar for the three drugs. Trimethyl-colchicinic acid has no effect on LTB4 generation. The suppressive effect of colchicine (1 x 10… (More)


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