Mechanism of action of colchicine in acute urate crystal-induced arthritis.

@article{Spilberg1979MechanismOA,
  title={Mechanism of action of colchicine in acute urate crystal-induced arthritis.},
  author={Isaias Spilberg and Brian Mandell and Jagdish Mehta and Louis Simchowitz and D. Rosenberg},
  journal={The Journal of clinical investigation},
  year={1979},
  volume={64 3},
  pages={775-80}
}
Phagocytosis of urate crystals by human or rabbit neutrophils induces the synthesis and release of a glycoprotein, the crystal-induced chemotactic factor (CCF), which is chemotactically active both in vitro and in vivo. It has been proposed that CCF is a prime mediator of the acute gouty attack. Colchicine has been shown to decrease the production and… CONTINUE READING