• Corpus ID: 4937890

Mechanism of action of antidepressants.

  title={Mechanism of action of antidepressants.},
  author={Francesc Casa{\~n}as Artigas and David J. Nutt and Richard C. Shelton},
  journal={Psychopharmacology bulletin},
  volume={36 Suppl 2},
A wide range of effective drugs is available for the treatment of major depression. The discovery of these agents has not always been the result of rational drug design. Tricyclic antidepressants formed the mainstay of treatment until the 1990s, and selective serotonin reuptake inhibitors (SSRIs) have dominated treatment over the last decade. However, the poor tolerability associated with tricyclic antidepressants and concerns about the efficacy of SSRIs has led to the search for alternative… 

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