Mechanism of action of and resistance to quinolones

  title={Mechanism of action of and resistance to quinolones},
  author={Anna F{\`a}brega and Sergi Madurga and Ernest Giralt and Jordi Vila},
  booktitle={Microbial biotechnology},
Fluoroquinolones are an important class of wide-spectrum antibacterial agents. The first quinolone described was nalidixic acid, which showed a narrow spectrum of activity. The evolution of quinolones to more potent molecules was based on changes at positions 1, 6, 7 and 8 of the chemical structure of nalidixic acid. Quinolones inhibit DNA gyrase and topoisomerase IV activities, two enzymes essential for bacteria viability. The acquisition of quinolone resistance is frequently related to (i… CONTINUE READING