Mechanism of action of and resistance to quinolones

@article{Fbrega2009MechanismOA,
  title={Mechanism of action of and resistance to quinolones},
  author={Anna F{\`a}brega and Sergi Madurga and Ernest Giralt and Jordi Vila},
  journal={Microbial biotechnology},
  year={2009},
  volume={2},
  pages={40 - 61}
}
  • Anna Fàbrega, Sergi Madurga, +1 author Jordi Vila
  • Published 2009
  • Medicine, Biology
  • Microbial biotechnology
  • Summary Fluoroquinolones are an important class of wide‐spectrum antibacterial agents. The first quinolone described was nalidixic acid, which showed a narrow spectrum of activity. The evolution of quinolones to more potent molecules was based on changes at positions 1, 6, 7 and 8 of the chemical structure of nalidixic acid. Quinolones inhibit DNA gyrase and topoisomerase IV activities, two enzymes essential for bacteria viability. The acquisition of quinolone resistance is frequently related… CONTINUE READING

    Figures, Tables, and Topics from this paper.

    Citations

    Publications citing this paper.
    SHOWING 1-10 OF 228 CITATIONS, ESTIMATED 60% COVERAGE

    Mechanisms of quinolone action and resistance: where do we stand?

    VIEW 9 EXCERPTS
    CITES BACKGROUND
    HIGHLY INFLUENCED

    Functional Characterization of the DNA Gyrases in Fluoroquinolone-Resistant Mutants of Francisella novicida

    VIEW 2 EXCERPTS
    CITES BACKGROUND

    Prevalence of mechanisms decreasing quinolone-susceptibility among Salmonella spp. clinical isolates.

    Plasmid-mediated quinolone resistance: Mechanisms, detection, and epidemiology in the Arab countries.

    • Iman Yassine, Rayane Rafei, +3 authors Monzer Hamze
    • Biology, Medicine
    • Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
    • 2019

    FILTER CITATIONS BY YEAR

    2007
    2020

    CITATION STATISTICS

    • 13 Highly Influenced Citations

    • Averaged 31 Citations per year from 2018 through 2020

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 239 REFERENCES

    Mechanisms of resistance to quinolones.

    • George A. Jacoby
    • Biology, Medicine
    • Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
    • 2005
    VIEW 2 EXCERPTS

    Mechanism of plasmid-mediated quinolone resistance

    VIEW 1 EXCERPT

    Advances in DNA gyrase inhibitors

    VIEW 2 EXCERPTS