Mechanism of action of a flavin-containing monooxygenase.

  title={Mechanism of action of a flavin-containing monooxygenase.},
  author={Subramaniam Eswaramoorthy and Jeffrey B. Bonanno and Stephen K. Burley and Subramanyam Swaminathan},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={103 26},
Elimination of nonnutritional and insoluble compounds is a critical task for any living organism. Flavin-containing monooxygenases (FMOs) attach an oxygen atom to the insoluble nucleophilic compounds to increase solubility and thereby increase excretion. Here we analyze the functional mechanism of FMO from Schizosaccharomyces pombe using the crystal structures of the wild type and protein-cofactor and protein-substrate complexes. The structure of the wild-type FMO revealed that the prosthetic… CONTINUE READING

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