Mechanism of action of a distal NF-kappaB-dependent enhancer.


The monocyte chemoattractant protein 1 gene (MCP-1) is regulated by TNF through an NF-kappaB-dependent distal enhancer and an Sp1-dependent promoter-proximal regulatory region. In the silent state, only the distal regulatory region is accessible to transcription factors. Upon activation by tumor necrosis factor, NF-kappaB binds to the distal regulatory… (More)


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@article{Teferedegne2006MechanismOA, title={Mechanism of action of a distal NF-kappaB-dependent enhancer.}, author={Belete Teferedegne and Myesha R Green and Zhu Jian Guo and Jeremy M Boss}, journal={Molecular and cellular biology}, year={2006}, volume={26 15}, pages={5759-70} }