Mechanism of action of CM-55, a synthetic analogue of the antilipogenic antibiotic cerulenin.

@article{Ohno1974MechanismOA,
  title={Mechanism of action of CM-55, a synthetic analogue of the antilipogenic antibiotic cerulenin.},
  author={T Ohno and Jonathan D. Awaya and Tadataka Kesado and Shuichi Nomura and Sohei Omura},
  journal={Antimicrobial agents and chemotherapy},
  year={1974},
  volume={6 4},
  pages={
          387-92
        }
}
CM-55 is a synthetic analogue of the antibiotic cerulenin with the chemical structure of 2, 3-dodecenyl-4-oxo-dimethyl amide. This compound inhibited the growth of Saccharomyces cerevisiae ATCC 12341 and inhibited protein and lipid synthesis by 91 and 95%, respectively, at a concentration of 50 mug/ml (2.1 x 10(-4) M). The inhibition of protein synthesis was associated with the partial reduction of ribonucleic acid synthesis and leucine transport. The mechanism of inhibition of lipid synthesis… CONTINUE READING