Mechanism of action-based classification of antibiotics using high-content bacterial image analysis.

@article{Peach2013MechanismOA,
  title={Mechanism of action-based classification of antibiotics using high-content bacterial image analysis.},
  author={Kelly C. Peach and Walter M. Bray and Dustin M Winslow and Peter F. Linington and Roger G. Linington},
  journal={Molecular bioSystems},
  year={2013},
  volume={9 7},
  pages={1837-48}
}
Image-based screening has become a mature field over the past decade, largely due to the detailed information that can be obtained about compound mode of action by considering the phenotypic effects of test compounds on cellular morphology. However, very few examples exist of extensions of this approach to bacterial targets. We now report the first high-throughput, high-content platform for the prediction of antibiotic modes of action using image-based screening. This approach employs a unique… CONTINUE READING

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