Mechanism of action and in vivo role of platelet-derived growth factor.

@article{Heldin1999MechanismOA,
  title={Mechanism of action and in vivo role of platelet-derived growth factor.},
  author={Carl-Henrik Heldin and Bengt Westermark},
  journal={Physiological reviews},
  year={1999},
  volume={79 4},
  pages={1283-316}
}
Platelet-derived growth factor (PDGF) is a major mitogen for connective tissue cells and certain other cell types. It is a dimeric molecule consisting of disulfide-bonded, structurally similar A- and B-polypeptide chains, which combine to homo- and heterodimers. The PDGF isoforms exert their cellular effects by binding to and activating two structurally related protein tyrosine kinase receptors, denoted the alpha-receptor and the beta-receptor. Activation of PDGF receptors leads to stimulation… CONTINUE READING
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HELDIN, AND L. CLAESSONWELSH. Grb7 is a downstream signaling component of plateletderived growth factor a- and b-receptors

  • K. YOKOTE, B. MARGOLIS, C.-H
  • J. Biol
  • 1996
Highly Influential
8 Excerpts

OSBORNE, AND B. MARGOLIS. The SH2 domain protein GRB-7 is co-amplified, overexpressed and in a tight complex with HER2 in breast cancer

  • D. STEIN, WU J., +5 authors C.K.A.M. BUCHBERG
  • EMBO J
  • 1994
Highly Influential
8 Excerpts

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