Mechanism of action and in vivo role of platelet-derived growth factor.

  title={Mechanism of action and in vivo role of platelet-derived growth factor.},
  author={Carl-Henrik Heldin and Bengt Westermark},
  journal={Physiological reviews},
  volume={79 4},
Platelet-derived growth factor (PDGF) is a major mitogen for connective tissue cells and certain other cell types. It is a dimeric molecule consisting of disulfide-bonded, structurally similar A- and B-polypeptide chains, which combine to homo- and heterodimers. The PDGF isoforms exert their cellular effects by binding to and activating two structurally related protein tyrosine kinase receptors, denoted the alpha-receptor and the beta-receptor. Activation of PDGF receptors leads to stimulation… CONTINUE READING
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