Mechanism of action and in vitro activity of 1',3'-dioxolanylpurine nucleoside analogues against sensitive and drug-resistant human immunodeficiency virus type 1 variants.

@article{Gu1999MechanismOA,
  title={Mechanism of action and in vitro activity of 1',3'-dioxolanylpurine nucleoside analogues against sensitive and drug-resistant human immunodeficiency virus type 1 variants.},
  author={Zhengxian Gu and Mark A. Wainberg and Nghe Nguyen-Ba and Lucille L'Heureux and Jean-Marc de Muys and Terry L. Bowlin and Robert F. Rando},
  journal={Antimicrobial agents and chemotherapy},
  year={1999},
  volume={43 10},
  pages={2376-82}
}
(-)-Beta-D-1',3'-Dioxolane guanosine (DXG) and 2,6-diaminopurine (DAPD) dioxolanyl nucleoside analogues have been reported to be potent inhibitors of human immunodeficiency virus type 1 (HIV-1). We have recently conducted experiments to more fully characterize their in vitro anti-HIV-1 profiles. Antiviral assays performed in cell culture systems determined that DXG had 50% effective concentrations of 0.046 and 0.085 microM when evaluated against HIV-1(IIIB) in cord blood mononuclear cells and… CONTINUE READING

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