Mechanism of action and clinical effects of antiprogestins on the non-pregnant uterus.

@article{Spitz1998MechanismOA,
  title={Mechanism of action and clinical effects of antiprogestins on the non-pregnant uterus.},
  author={Irving M. Spitz and A. Robbins},
  journal={Human reproduction update},
  year={1998},
  volume={4 5},
  pages={
          584-93
        }
}
Considerable progress has been made in elucidating the mechanism of action of antiprogestins. The biological response to a progesterone antagonist depends on many factors. The usual effect is that of an antagonist, but progesterone agnostic or even antioestrogenic or oestrogenic effects have also been observed. The present review focuses on the clinical applications of antiprogestins in the non-pregnant uterus. Whereas high doses of antiprogestins block ovulation, low doses impair endometrial… CONTINUE READING

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