Mechanism of acetaminophen-induced hepatotoxicity: covalent binding versus oxidative stress.

@article{Gibson1996MechanismOA,
  title={Mechanism of acetaminophen-induced hepatotoxicity: covalent binding versus oxidative stress.},
  author={James D. Gibson and Neil R. Pumford and Victor M Samokyszyn and Jack A. Hinson},
  journal={Chemical research in toxicology},
  year={1996},
  volume={9 3},
  pages={580-5}
}
The hepatotoxicity of acetaminophen is believed to be mediated by the reactive metabolite N-acetyl-p-benzoquinone imine; however, the mechanism by which this metabolite produces the toxicity is unknown. The metabolite, which is both an electrophile and an oxidizing agent, may covalently bind to critical proteins, or it may initiate oxidative damage. We have… CONTINUE READING