Mechanism of acetaldehyde-induced deactivation of microbial lipases

  title={Mechanism of acetaldehyde-induced deactivation of microbial lipases},
  author={Benjamin Franken and Thorsten Eggert and Karl-Erich Jaeger and Martina Pohl},
  booktitle={BMC Biochemistry},
Microbial lipases represent the most important class of biocatalysts used for a wealth of applications in organic synthesis. An often applied reaction is the lipase-catalyzed transesterification of vinyl esters and alcohols resulting in the formation of acetaldehyde which is known to deactivate microbial lipases, presumably by structural changes caused by initial Schiff-base formation at solvent accessible lysine residues. Previous studies showed that several lipases were sensitive toward… CONTINUE READING
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