Mechanism of acetaldehyde-induced deactivation of microbial lipases

@inproceedings{Franken2010MechanismOA,
  title={Mechanism of acetaldehyde-induced deactivation of microbial lipases},
  author={Benjamin Franken and Thorsten Eggert and Karl-Erich Jaeger and Martina Pohl},
  booktitle={BMC Biochemistry},
  year={2010}
}
Microbial lipases represent the most important class of biocatalysts used for a wealth of applications in organic synthesis. An often applied reaction is the lipase-catalyzed transesterification of vinyl esters and alcohols resulting in the formation of acetaldehyde which is known to deactivate microbial lipases, presumably by structural changes caused by initial Schiff-base formation at solvent accessible lysine residues. Previous studies showed that several lipases were sensitive toward… CONTINUE READING
Highly Cited
This paper has 123 citations. REVIEW CITATIONS
5 Citations
71 References
Similar Papers

References

Publications referenced by this paper.
Showing 1-10 of 71 references

Enhancement of the stability of a prolipase from Rhizopus oryzae toward aldehydes by saturation mutagenesis

  • M DiLorenzo, A Hidalgo, R Molina, JA Hermoso, D Pirozzi, UT Bornscheuer
  • Appl Environ Microbiol
  • 2007

Formation of secondary light-absorbing “fulvic-like” oligomers: A common process in aqueous and ionic atmospheric particles

  • B Nozière, P Dziedzic, A Córdova
  • Geophys Res Lett 2007,
  • 2007
3 Excerpts

Similar Papers

Loading similar papers…