Mechanism of a flow-gated angiogenesis switch: early signaling events at cell-matrix and cell-cell junctions.

@article{Vickerman2012MechanismOA,
  title={Mechanism of a flow-gated angiogenesis switch: early signaling events at cell-matrix and cell-cell junctions.},
  author={Vernella Vickerman and Roger D Kamm},
  journal={Integrative biology : quantitative biosciences from nano to macro},
  year={2012},
  volume={4 8},
  pages={
          863-74
        }
}
A bias towards angiogenesis from the venous circulation has long been known, but its cause remains unclear. Here we explore the possibility that high interstitial pressure in tumors and the resultant net filtration pressure gradient that would induce flow from the interstitium into the venous circulation or lymphatics could also be an important mechanical regulator of angiogenesis. The objective of this study was to test the hypothesis that basal-to-apical (B-A) transendothelial flow promotes… CONTINUE READING
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