Mechanism of a concentration-dependent switch between activation and inhibition of Arp2/3 complex by coronin.

@article{Liu2011MechanismOA,
  title={Mechanism of a concentration-dependent switch between activation and inhibition of Arp2/3 complex by coronin.},
  author={Su-Ling Liu and Karen M Needham and Jordan R May and Brad J. Nolen},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 19},
  pages={17039-46}
}
Arp2/3 complex is a key actin filament nucleator that assembles branched actin networks in response to cellular signals. The activity of Arp2/3 complex is regulated by both activating and inhibitory proteins. Coronins make up a large class of actin-binding proteins previously shown to inhibit Arp2/3 complex. Although coronins are known to play a role in controlling actin dynamics in diverse processes, including endocytosis and cell motility, the precise mechanism by which they regulate Arp2/3… CONTINUE READING
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