Mechanism of a Reaction in Vitro Associated with Delayed-Type Hypersensitivity

@article{Bloom1966MechanismOA,
  title={Mechanism of a Reaction in Vitro Associated with Delayed-Type Hypersensitivity},
  author={B. Bloom and B. Bennett},
  journal={Science},
  year={1966},
  volume={153},
  pages={80 - 82}
}
  • B. Bloom, B. Bennett
  • Published 1966
  • Biology, Medicine
  • Science
  • The cell type responsible for inhibition by antigen of migration in vitro of peritoneal exudate cells obtained from tuberculin-hypersensitive guinea pigs was studied. Exudate populations were separated into component cell types, the lymphocyte and the macrophage. Peritoneal lymphocytes from sensitive donors were the immunologically active cells in this system, the macrophages, being merely indicator cells which migrate. Sensitized peritoneal lymphocyte populations, upon interaction with… CONTINUE READING

    Topics from this paper.

    ALTERATIONS OF MACROPHAGE FUNCTIONS BY MEDIATORS FROM LYMPHOCYTES
    189
    LYMPHOID CELLS IN DELAYED HYPERSENSITIVITY
    8
    A PLAQUE ASSAY FOR ENUMERATING ANTIGEN-SENSITIVE CELLS IN DELAYED-TYPE HYPERSENSITIVITY
    26

    References

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    • 1965
    PPD's used for these experiments were suLpplied by Merck, Sharpe and Dohme, West Point, Pa., and the Ministrv of Agriculture, Fisheries and Food
      Supported by PHS grants Al 04131, Al 07118, and CA-08145. We thank Dr. J. Battisto and Dr. D. Follett for advice and criticism
        Supported by PHS grants GM-10112 and CA-06927 and American Cancer Society grant IN-49F. We thank G. T. Rudkin for aid with the statistical analysis
          The chambers wvere a modification of that described by G. B. Mackaness
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