Mechanism of Transcriptional Silencing in Yeast

  title={Mechanism of Transcriptional Silencing in Yeast},
  author={Lingyi Chen and Jonathan Widom},
Transcriptional silencing is a phenomenon in which the transcription of a gene by RNA polymerase II or III is repressed or not, dependent only on the gene's chromosomal location. Two prevailing models exist for silencing: (1) steric hindrance in silenced chromatin inhibits the binding of upstream activator proteins or polymerase or (2) silencing primarily blocks steps downstream of transcription preinitiation complex formation. Here, we test these models quantitatively for the case of SIR2… CONTINUE READING


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A Genetic Switch: Phage Lambda Revisited, Third Edition (Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press)

  • M. Ptashne
  • 2004
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