Mechanism of Telapristone Acetate (CDB4124) on Progesterone Receptor Action in Breast Cancer Cells.

@article{Davaadelger2018MechanismOT,
  title={Mechanism of Telapristone Acetate (CDB4124) on Progesterone Receptor Action in Breast Cancer Cells.},
  author={Batzaya Davaadelger and Alina R. Murphy and S. Clare and O. Lee and Seema A. Khan and J. Kim},
  journal={Endocrinology},
  year={2018},
  volume={159 10},
  pages={
          3581-3595
        }
}
Progesterone is a steroid hormone that plays an important role in the breast. Progesterone exerts its action through binding to progesterone receptor (PR), a transcription factor. Deregulation of the progesterone signaling pathway is implicated in the formation, development, and progression of breast cancer. Next-generation selective progesterone receptor modulators (SPRMs) have potent antiprogestin activity and are selective for PR, reducing the off-target effects on other nuclear receptors… Expand

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